Efficient Chemical Synthesis and Oxidative Folding Studies of Scorpion Toxin Peptide WaTx
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چکیده
منابع مشابه
nano-rods zno as an efficient catalyst for the synthesis of chromene phosphonates, direct amidation and formylation of amines
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Scorpion toxin peptide action at the ion channel subunit level
This review categorizes functionally validated actions of defined scorpion toxin (SCTX) neuropeptides across ion channel subclasses, highlighting key trends in this rapidly evolving field. Scorpion envenomation is a common event in many tropical and subtropical countries, with neuropharmacological actions, particularly autonomic nervous system modulation, causing significant mortality. The prim...
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1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...
Small efficient cell-penetrating peptides derived from scorpion toxin maurocalcine.
Maurocalcine is the first demonstrated example of an animal toxin peptide with efficient cell penetration properties. Although it is a highly competitive cell-penetrating peptide (CPP), its relatively large size of 33 amino acids and the presence of three internal disulfide bridges may hamper its development for in vitro and in vivo applications. Here, we demonstrate that several efficient CPPs...
متن کاملChaperone-mediated native folding of a β-scorpion toxin in the periplasm of Escherichia coli☆
BACKGROUND Animal neurotoxin peptides are valuable probes for investigating ion channel structure/function relationships and represent lead compounds for novel therapeutics and insecticides. However, misfolding and aggregation are common outcomes when toxins containing multiple disulfides are expressed in bacteria. METHODS The β-scorpion peptide toxin Bj-xtrIT from Hottentotta judaica and fou...
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ژورنال
عنوان ژورنال: Acta Chimica Sinica
سال: 2022
ISSN: ['0567-7351']
DOI: https://doi.org/10.6023/a21120580